Proteoglycans in the arterial wall contain unbranched carbohydrate polymer glycosaminoglycans, which play important role in the retention of lipoproteins on the arterial wall resulting in the development of atherosclerotic diseases.¹  Interaction occurs between negatively charged groups on the glycosaminoglycans and with the clusters of positively charged amino acid on lipoproteins. Partial filling affinity capillary electrophoresis and quartz crystal microbalance have previously been shown to be efficient biomimicing analytical techniques to gain more information of extra cellular matrix interactions.^2,3  Recently, we have developed new, efficient noncovalent noncovalent poly(N-methyl-2-vinylpyridinium iodide- block- ethylene oxide) coating for the capillary electrophoresis to prevent strong interaction between lipoproteins and capillary wall, and this coating is employed to study interactions between human lipoproteins and glycosaminoglycans in more detail. Furthermore, different monoliths have been used as complementary tool for the interaction studies and also for the purification of biomaterials.