In parallel segmented flow chromatography (PSF) the flow of the mobile phase is dynamically managed as it passes through the HPLC column, to eliminate wall effects and minimise solute band broadening, therefore maximising the performance of the column. This is achieved by separating the central flow region of the bed from the peripheral or wall flow region using an annular frit design, and a multi-channel end fitting.

The practical advantages of using PSF have been described in the literature for fully porous [1,2] and monolithic materials [3]. In this paper we report the results of a study comparing the performance of two column configurations (standard and PSF) where the columns are packed with solid core particles. Peak efficiency, peak asymmetry and peak height are monitored. Significant improvements are observed, with PSF providing up to 20% higher efficiencies, 5-10% improved peak height and more symmetrical peaks.