Fast determination of 22 sulfonamides from chicken using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer as adsorbent followed by liquid chromatography–tandem mass spectrometry — ASN Events

Fast determination of 22 sulfonamides from chicken using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer as adsorbent followed by liquid chromatography–tandem mass spectrometry (#158)

Micong Jin 1 , Yonggang Zhao 1
  1. Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China, China

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides in chicken by using the dispersive micro-solid-phase extraction (d-µ-SPE) procedure combined with ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS). The excellent core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer (CS-NR-Mag-MIP) was used as an adsorbent, and the main factors affecting the extraction efficiency were investigated in detail. All target compounds showed good linearities in the tested range with correlation coefficients (r) higher than 0.9993. The mean recoveries were in the range of 72.0-109.2%. The intra-day and inter-day relative standard deviations (RSDs) were lower than 5.9% and 7.2%, respectively. The limits of quantification for the 22 sulfonamides were between 0.025-0.56 µg•L-1. The developed method can be applied to the routine analyses for the determination of the 22 sulfonamides in chicken samples.